Release of redox enzymes and micro-RNAs in extracellular vesicles, during infection and inflammation

Many studies reported that redox enzymes, particularly thioredoxin and peroxiredoxin, can be released by cells act as soluble mediators in immunity. Recently, it became clear peroxiredoxins secreted via the exosome-release route, yet remains unclear how this exactly happens why. This review will first introduce briefly possible states of protein cysteines role enzymes their regulation. We then discuss on extracellular forms some these association with exosomes/extracellular vesicles exosome micro-RNAs (miRNAs)/mRNAs involved oxidative processes, relevant infection inflammation.